Be careful of what medications you're taking together. | asthmalibrary.com Benadryl and Unisom can make you excessively sleepy if taken together. An overdose of ibuprofen can cause damage to your stomach or intestines. Do not take diphenhydramine and ibuprofen without medical advice if you are. Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this.
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